Medoc PATHWAY - Figure 3: Ramp &Hold Sequence - Return to Baseline

Pathway Technical Reference Manual
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Temperature
Time
Baseline
Temperature
Destination
temperature
Onset
Destination
Temperature
End of
Duration
Duration
Time
Time
Before
Sequence
Onset-to-Onset Time
Trial 1
Trial 2
End-to-Onset
Time
Sequence 1
Start Test
End Test
Figure 3: Ramp &Hold Sequence – Return to Baseline
Each sequence consists of a number of similar trials (one trial is also allowed).
1. The start point of each trial is called onset.
The temperature at this point (the onset point) is the Baseline Temperature defined for this
sequence.
2. From this point the temperature changes at a predefined rate, until it reaches the
predefined Destination Temperature.
3. Then, the temperature remains at the destination temperature level for the predefined
duration time. The point at the end of the duration time is called end of duration.
Setting duration time to zero produces peaks.
4. Finally, the temperature returns at the return rate, to the baseline temperature. The
temperature remains at this level for a duration that can be specified in one of two ways:
as an end-to-onset time or an onset-to-onset time.
At the start of each sequence the temperature should remain at the Baseline Temperature
level for the time given by the parameter Time Before Sequence.
2.8.1.2 “Return to the Next Destination” option
The temperature at the End of Duration point goes directly to the Destination Temperature of
the next sequence when this option is used.
This is available only for sequences consisting of one trial.
See definition of each parameter in section 7.7.1, page 71.