Siemens Rapidlab 1200 - Interference Testing; Interference Testing for Rapidlab 1200 Sensors

E-6 Rapidlab 1200 Operator’s Guide: System Specifications
02087462 Rev.V
Interference Testing
Interference Testing for Rapidlab 1200 Sensors
Siemens performed interference testing to demonstrate the specificity of the system
sensors.
The results from each of the studies were tabulated and the simple average effect was
determined for each interfering compound. The Effect of Interference column
demonstrates the apparent change in result as a function of introducing the interfering
compound. In several instances multiple tests were performed on an interfering substance
as well as several levels of interfering substance.
The effect of the potential interfering substance on results is summarized in the following
table. The table shows the interference level tested along with the average change in blood
results (test result spiked - control result unspiked) for each of the sensors.
Analyte (units) Interference
Interference
Level Tested
Effect of
Interference
(Test - control)
pH (pH units) Acetaminophen 20 mg/dL 0.000
Sodium Pentothal 300 mg/dL -0.009
Salicylic Acid 20 mg/dL 0.000
pO
2
(mm Hg) Isoflurane 3% 0.15
Halothane 3% 0.05
Nitrous Oxide 84% 2.8
pCO
2
(mm Hg) Ibuprofen 40 mg/dL 0.35
Sodium Pentothal 300 mg/dL 1.34
Na
+
(mmol/L)
Acetaminophen 2 mg/dL 0.00
Dobutamine 20 mg/dL 0.37
Dobutamine 10 mg/dL 0.15
Dobutamine 5 mg/dL 0.20
Na
+
(mmol/L)
Vancomycin 63 µg/dL -0.23
Ofloxacin 6 µg/dL -0.14
Perphenazine 1.25 µg/mL 0.05
Sodium Pentothal 300 mg/dL -0.88
K
+
(mmol/L)
Sodium Pentothal 300 mg/dL -0.016
Cl
-
(mmol/L)
Heparin 90 units/mL 0.5
Salicylic Acid 30 mg/dL 1.0
Salicylic Acid 20 mg/dL 0.7