GE CARESCAPE - Entropy reference studies; Entropy reference studies supporting reduction of drugs; Entropy reference studies supporting titration of drugs

Entropy
Entropyreferencestudies
Entropyreferencestudiessupportingreductionofdrugs
Thefollowingstudiessupporttheindicationforreducingtheamountofcertainhypnotic
drugsandenablingfasteremergencefromanesthesia:
●VakkuriA,Yli-HankalaA,SandinR,MustolaS,HoymorkS,NyblomS,TaljaP,SampsonT,
VanGilsM,Viertiö-OjaH:SpectralEntropymonitoringisassociatedwithreducedpropofol
useandfasteremergenceinpropofol-nitrousoxide-alfentanilanesthesiaAnesthesiology
2005,Volume103,Issue2:274-279,2005
InthestudyreportedbyVakkurietalusingpropofol,Entropymonitoringhelped
indeterminingthetitrationratesofpropofolespeciallyduringthelastpartofthe
procedures.Thisisindicatedbyhigherentropyvalues,decreasedconsumptionof
propofol(P<0.001),andshorterrecoverytimesintheEntropymonitoredgroup
●AiméI,VerroustN,Masson-LefollC,TaylorG,LaloePA,LiuN,FischlerM(2006):Does
monitoringbispectralindexorspectralentropyreducesevouraneuse?AnesthAnalg
103:1469-77
InthestudybyAiméetal,theauthorsreportedthattheywereabletocutdownthe
sevouraneusageby29%intheEntropymonitoredgroup,whencomparedtothe
standardclinicalpractice.
Entropyreferencestudiessupportingtitrationofdrugs
ThefollowingstudiessupporttheindicationthatuseofEntropymayhelptheusertotitrate
certainanestheticdrugsaccordingtotheindividualneedsofadultpatients:
●VanlucheneA.L.G.,VereeckeH,ThasO,MortierE.P,ShaferS.L,StruysM.M.R.F
SpectralEntropyasanElectroencephalographicMeasureofAnestheticDrugEffect:A
ComparisonwithBispectralIndexandProcessedMidlatencyAuditoryEvokedResponse
Anesthesiology2004;Volume101:Issue1:34–42.
InthisstudybyVanlucheneetalusingpropofol,theauthorsconcludethatbothSEand
REseemtobeusefulmeasuresforanestheticdrugeffect,withlowbaselinevariability
andaccurateburstsuppressiondetection.
●VanlucheneA.L.G,StruysM.M.R.F,HeyseB.E.K,MortierE.P:Spectralentropy
measurementofpatientresponsivenessduringpropofolandremifentanil.Acomparison
withthebispectralindex.BritishJournalofAnaesthesia2004;Volume93:Issue5:645–54.
InthisstudybyVanlucheneetalusingpropofol,theauthorsconcludethatlossof
responsetoverbalcommandandlossofresponsetonoxiousstimulationwereaccurately
detectedbyEntropyandBIS.
●VakkuriA,Yli-HankalaA,TaljaP,MustolaS,Tolvanen-LaaksoH,SampsonT,Viertiö-Oja
H:Time-frequencybalancedspectralentropyasameasureofanestheticdrugeffectin
centralnervoussystemduringsevourane,propofol,andthiopentalanesthesiaActa
AnaesthesiologicaScandinavica2004;Volume48:Issue2:145-153,2004.
Inthisstudyusingsevourane,propofolandthiopental,theauthorsfoundthatSEand
REdistinguishedexcellentlybetweenconsciousandunconsciousstates.Theauthors
concludethatREindicatesemergencefromanesthesiaearlierthanSEorBIS.
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